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    VIP #48                                                                                         Jun 29, 2021

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Question
How can I get a better understanding of how to adjust my diet to burn more fat/lose weight. Is there a way to understand the ideal macros that I should be consuming each day to facilitate weight loss?
I subscribed and bought Test Kit from selfDecode since 12-29-2020, but I never using the service because I don't know using internet. I belieive I have leaky gut and affect my mental health, bad constipation, brain fog, depresss etc.... How selfdecode and you can help me. I need your help. Please give me steps what I should do. I thank you and appreciate.
joe I had a major consuccuion and started to get brain fog and inflammation in the brain after that gradually, I am eating a meat based diet and while my inflammation went down it wasn't 100% gone and I tried the ices on full intensity for an hour, I felt an instant relief after 3 hours and its been down ever since, can you please tell me what was the problem blood flow? or something you can think that it fixed or targeted?
hey joe when you changed your diet did your inflam go down all the way or did you have use supplements or other devices like llt or ices to control it further? also did your brain function got better due to diet did you use supplements from your DNA reports to enhance it further and if what was the best one that worked for you?
1: joe I have checked my food sensitivities report and it shows I’m lactose intolerant and sensitive to food additives. But dosent say anything about lectins or carbohydrates or gluten, yet when I eat anything other than meat like chicken beef and fish, I get inflammation. I am currently doing LAD but wanted to ask if you have came across people that don’t have the bad genes and are still sensitive? Also do you think this could be a leaky gut issiue and if so what would you advice moving forward to tackle it? Should I eat foods i don’t react to and then let me gut heal and then reintroduce them after or what would be a good way to go about it? 2: joe would you recommend trying to introduce supplements from my reports like mood and cognition after I get my diet in order and let my gut heal, and then start the supplements? Also did you start taking supplements when you were not inflamed like when you got you deit in order and the. You started the supplements for mood and cognition? If you are inflamed or deit isn’t good then the supplements woudnt do you any good right?
HI, I was diagnosed with a rare genetic condition, Ehlers Danlos, type 3 at age 56. Are there certain ways your genetic reports could indicate issues with connective tissue disorders? Thank you
I have not noticed any recommendations on the use of Homeopathic or Herbal remedies. Are they not accepted by Selfhacked ?
Hi Joe, I recently purchased your cookbook. Please could you share what you specifically eat each day of the week currently, as I would like to just try eating exactly the same meals for a few months (as I seem to be sensitive to the same foods you are). Thank you.
hey, joe 1. I am dealing with chronic issues and wanted to know how would you go about addressing toxins an infection issues, how would you know that the issue and how to address them? 2. do you believe that eating meat( chicken/fish/beef) plus organs with olive oil too much-saturated fats? and consume hi maize and honey. 3. what do you think becomes access protein I consume 2lb beef/day. should I add veggies is not sensitive even though I have read lots of bad things about veggies, what are your thoughts on veggies ? or stick to cruciferous veggies?
Which is better at lowering estrogen in men, sulforaphane, I3C 400mg, or DIM 300mg?
Recent studies are trying to link fish oil with A-fib. Is 4-6 gms per day too much or dangerous?
I have heard that you shouldn't use wormwood for parasites if you have high iron blood labs. Thoughts?
Read where fisetin/fenugreek, quercetin, theaflavins, sulforaphane stack enhances autophagy while fasting. Are there others to add to stack?
Clients are having challenges navigating the self decode site in order to read their results. Would you be able to escort us through the site that clients utilize so we can be better prepared to guide them through? I'm wondering if others are having this challenge. Thanks very much!
If I am continuing to have high iron and ferritin blood labs which genetic code should I look at?
How can we measure our inflammation? Is there a fast and effective way we could do say on a monthly basis?
I've been a self decode and LTA member for years and I love the work they are doing. Just keep in mind that just because you have certain SNP's that it doesn't mean they are expressing. You can look at all the hall marks of a certain SNP and you can identify with the vast majority of them then there is a good chance it is expressing. epigenetics can also flip genes on and off. Just keep that in mind because a lot of people will see their report and think just because it says you have a homozygous SNP you have issues, just be aware it's not that clear cut.
What are your recommendations regarding the best fats for someone with APOE E/3 E/4?
Are their specific genes or group of genes that are involved in osteoporosis/osteopenia?
A lot of times people with gut infections will have high ferritin due to the fact that the immune system will pull iron away from invading bacteria that feed on it in an attempt to starve it out. However the side effects are that it has to store the iron. This can be overcome by donating blood every 8 weeks while you get you gut infection under control.
Do you test for SUOX gene?
Hi do you have info on ppara rare snp. I have GG and my kids have GC. Mine says 0%. Is this why we struggle with weight? Thanks

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 VIP #48                                                         JUN 29, 2021

Question
Final note to my big questions below: I think it was vitamin K (K1, MK4, MK7) causing my BP issues!? I'm starting to take 10k D without any K. PS: What's the Group Consult for?
I have tried several times to unsubscribe from VIP service but you keep charging me. I have evidence from many emails and only one response. I really enjoyed for several years your service but this is unprofessional. I know you are probably not even aware of this and that this is not the place for this, but you should have venues to solve problems like this.
Do you know any particular hack/solution to overcome waking up at night at about 1-3 am? Most of the time I fall asleep very quickly, then I wake up after the first or second sleep cycle. Usually, I don't feel tired after and it is really hard to fall back to sleep. It takes much time for me to feel tired again and fall back to sleep again, but even when I can I have a lighter sleep. According to your sleep report, I have lower-than-average risk for insomnia-like symptoms.
A few other observations on top of my first message, My Oura is tracking a -5-8 dip in BPM at the moments I wake up (~2am, ~3:30, sometimes midnight). When I had a Fitbit it tracked a -7-10% dip in oxygen (Pulse Ox) around those same times (before megadosing D). With the D+licorice interaction I had super high and sensitive BPM during the day, so that still points me to aldosterone/etc imbalance. But are these ox/BPM dips related? Are they just sleep apnea? But if so, why at very specific times? I've been looking into trying nitric oxide supplementation but am not sure if it fits this picture?
I've gotten myself into an odd situation with Vitamin D so bear with me please. I've been chronically deficient (VDR SNPs confirmed, maybe absorption issues too?) so I feel I need to supplement for life, but I'd been neglecting it for years because no doctor prioritized it. So last October - November I megadosed 25k-70k daily for a few weeks to force my levels into optimal range (D3 + 3 Ks was most effective) , mainly because I was in pursuit of resolving a severe, chronic cluster of health issues: 1-3-day-long, post-meal "hangovers" involving lethargy, cognitive impairment, eye pain / uveitis, loss of appetite, and mood issues (which I'd asked you about a couple months ago too). I got a blood test and overshot it of course (196 ng/mL of 25OH with calcitriol at 80pg), yet had ZERO negative side effects. This megadosing experiment DID IMPROVE those symptoms which had not responded to anything else for three years, and then completely disappeared like a miracle with slippery elm! (So clearly there was a gut-immune connection; I found your Tregs article which seems relevant). HOWEVER, to try supporting my continuing adrenal/HPA fatigue. I experimented with about 3 days of licorice root/tea at the end of my megadosing phase and my blood pressure skyrocketed to scary levels. I took myself to MedExpress, before connecting the dots: stopping D immediately lowered the high daytime BP. But I was left in a pattern of 3am awakenings for months, finally resolved a few weeks ago with 3000mg (3x) Seriphos and eating glucose Extend bars before bed. (My hunger/metabolism is through the roof, along with shaky body temp / temp sensitivity) Then recently, some of those "hangover" symptoms popped back up. I connected the dots to being 4 months off D, so I took 45k again across two days. Maybe it was too much? Because my sleep has been disturbed with 2am AND 3-4am high BP awakenings, where I can't fall back to sleep after the second awakening. I finally realized this is more likely aldosterone than cortisol? This BP is very 'calm but heavy', whereas cortisol BP always had a clear physical-mental-emotional stress associated with it and responded to Seriphos. My 3x Seriphos before bed has lost its efficacy with this non-stress BP. Taking another 1x with the second awakening might be helping me get back to sleep 2-3 hours later, but also wipes out my morning cortisol/oomph. So. What body equilibrium/system involving D/aldosterone/cortisol/adrenals/electrolytes did licorice screw with, that taking D is producing aldosterone-based insomnia? What am I missing? Based on two blood tests 45 days apart, my 196 levels dropped to 78 at a rate of losing ~2.4ng / day, so I don't think I can go too long with out D. But it's like I traded severe gut-immune symptoms for crazy insomnia, and there's a balance in between that I'm missing and don't know how to get back to. I feel like if I'd never experimented with licorice (the one thing I didn't research enough in my whole life!!!), then the combo of D + slippery elm + glucose management + Seriphos would've supported all of my issues and left me in a good place. Eager for your insight. Thank you.
I was wondering if I could schedule an appointment with you. Brain fog has become a big part of my life, and it's really made working difficult. My forehead always feels tight and it has become very hard to concentrate. I've been trying to treat my brain fog but so far it has been to no avail. Any help would be immensely appreciated.
My DHEA is high, I don't take supplements. I can find lots of info about low DHEA but not high. What are the implications of having a high DHEA the blood test results came back saying 7.14 umol/L out of range
Any particular reason why NAC isn't in your regimen?
Do you have any advice on weaning off from Otrivine for someone who suffers allergic nasal congestion at night?
"HLA-DQ8 even without HLA-DQ2 still seems to confer a 5-10% risk of celiac disease. It seems that selfdecode does not report this risk as below ... ""rs7454108 tags the HLA-DQ8 haplotype"" https://www.snpedia.com/index.php/Celiac_disease ""DQ8-positive HLA-DQA1*03 and HLA-DQB1*0302 5%-10%"" https://www.ncbi.nlm.nih.gov/books/NBK1727/ ""rs7454108 is not linked to any genes. Your genotype is TT"" https://selfdecode.com/snp/rs7454108/ Am I missing something? Kind regards from New Zealand :)"
I just wrote in a question about RA/Carnivore. I meant to also write I am APOE 3/4 so how do I address the saturated fat issue? Thanks.
I am somewhere on the arthritis spectrum, possibly RA (it's painful and in all matching joints). Last summer I went carnivore which helped a ton, but a simultaneous large increase in a calcium supplement gave me C-Diff. My joint pain is unmanageable and I want to carefully return to as close to carnivore as possible. I think I need to keep some level of carb because I have Hashimotos and sleep/ feel better with it. Can you suggest how I would best do this? Soaked rice over vegetables? I've tried everything else- AIP, Keto, Paleo and the arthritis stays with me. Any other suggestions?

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