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    VIP #47                                                                                         May 28, 2021

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Question
Firstly, thank you Joe for answering all of the questions and for your recent upgrades to the SelfDecode platform. Questions: 1. Will SD do anything similar to GenoPalate? (https://www.genopalate.com/). This would be really useful to help synthesize all of the recommendations and the Minerals and Vitamins report. Or will this be done via "My Regimen" where we put it together ourselves? 2. Do you have any suggestions for at home tests for allergies, inflammation, toxins, microbiome etc. that can be ordered and administered by an individual? It's hard to convince a doctor to order tests all the time, and I'd like to do them myself on my own time. 3. Do you have any suggestions on how we can measure our baseline of health? I am looking to get into biohacking but I want to be able to measure my progress. I have a FitBit, Oura, etc. but I am looking for further tips. Do you suggest those wearable blood glucose monitors? Thank you so much!
I have gluten sensitivity and would like to know what my genes show regarding that issue. How can I find out if I have the genetic marker for HLA-DQ2 and DQ8 and/or HLA-DQ1 and DQ3? Is that included in your testing? (which I have had done).
I have been injured by medication that I took as prescribed for 15 years. I have been trying to heal for 7 years. I am able to walk and talk again but I have severe motion sensitivity and balance so I have not been able to ride in a car or go anywhere for these last 7 years. I have worked my way up to navigating a grocery store nearby and it has been quite a journey. I am too sensitive for supplements still. Do you have any suggestions to help me with my balance and vision and weight! I am morbidly obese. I walk almost 3 miles a day. I am still fighting for my life and any suggestions are appreciated.
I'd like to know how the following supplements interact with my genetics and if there's parts of self-decode I can go to and research what genes they affect negatively or positively: 5htp, St Johns Wort, Lithium Orotate, etc.
I'd like to know about low-cost options for blue light blocking sunglasses
Hi Joe. Please review all the ways to lower homocysteine, especially if B vitamins are probably OK because I take them. (I do have c677t homozygous). Mine is approaching 15. I am caught between going more vegetarian or more carnivore, but meat has methione. Also, I have like a pound of hi-maize powder that's been on the shelf awhile. I can't imagine it goes bad. How do I take it - in water? how much? thank you.
Hi Joe, I have many digestive issues. I bought butyrate some time ago and took it in the evening. I only took it twice. Both times I woke up in the middle of the night with my digestive tract feeling like it was on fire. I've had fever before that the heat I felt after taking butyrate, made a fever of a 100 degrees feel like taking a cold shower. I thought I was going to die. Needless to say, I stopped taking it. Do you know what could have caused this reaction? I do have dysbiosis, SIBO, leaky gut, candida, probably parasites and other gut issues. Thanks.
I read that 25% of the population is a carrier (and sufferer) of the HLA-DR gene. How do I find this information? Thank you.
hey, joe, i have been getting some improvements from inflammation from using the ices, and wanted to know I have used it for 4 days and really love the anti-inflammatory effect it has on my brain, do you think I should take a break from it or keep at it daily?
hey joe, I have a request, can you make a video or write a post about how your journey was like battling with brain fog and other mental illness when you had inflammation, what you tried what was the result, and how you adjusted to different diets and things that helped you, it would be really insightful and would help a lot of people out thanks.
joe i took some supplements like lithium and galantamine and alpha-gpc from my cognitive report, but at the time I was really inflamed and i didn't see any benefits from it, do you think it's cause i was inflamed that it wasn't working? do you think they weren't working cause I was neuro-inflamed?
What is the current opinion of NMN vs NR?
How do you interpret the new studies saying fish oil has no effect on cardiac health?
How do you factor in the “epigenetic” side of gene expression in your reports: in other words, you may have a gene that makes you more susceptible to something undesirable, but if your gene isn’t turned on, will it matter? How do you bridge that gap in your findings?
why is my TGFBeta 1, VIP, VEGF, MMP9 so high- in testing these markers are you suppose to fast? If you didn't fast does that affect the reults
If your villie are too damaged, it exposes the stem cells at its root, and butyrate can then damage these
What do you think about Ahiflower Oil for vegan omega 3
When might it be a good idea to use an amino acid complex? I am 70 and have heard we need more protein as we age, but I’m not sure eating more meat is a good idea and I don’t eat legumes. TY
Could periods of fasting change metabolic rate. I have increased by baseline weight after each 5 day fasting mimicking diet. Could it be related to genetic FTO gene?
Would I need to decrease other supplements to start humic and fluvic complex products?
Great job on the webinar! I have pretty extensive experience with sub-q peptides, (cjc-1295, ipamorelin, etc), but have not been blown away by the effects. Lately I've seen promising anecdotal reports on sub-q and IM delivered aminos such as L carnitine, taurine, carnosine, and others. Do you have any opinion on the efficacy of oral vs injectable delivery methods for amino supplementation?
Is Calcium ß-Hydroxy-ß-Methylbutyrate Monohydrate safe for building/maintaining muscle in the elderly?
Why would require extremely high estradiol levels (surgical menopause 15 years) to have a level mood? Over 250 pg/ml to have any kind of sanity. Most doctors will not keep me at this level. My mood increases but my weight has ballooned. Does the estradiol increase dopamine or seratonine? other ways to stabilize mood instead of super high estradiol
glyphosates primary effects your gut bugs (microbiome), it has little effect on mammals other than their microbiome, which is problematic. Glyphosate interferes with the shikimate pathway which is not used in mammals but is used in many microbes. https://en.wikipedia.org/wiki/Glyphosate Glyphosate keeps our food prices low. So it is a trade off.

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 VIP #47                                                         MAY 28, 2021

Question
Final note to my big questions below: I think it was vitamin K (K1, MK4, MK7) causing my BP issues!? I'm starting to take 10k D without any K. PS: What's the Group Consult for?
I have tried several times to unsubscribe from VIP service but you keep charging me. I have evidence from many emails and only one response. I really enjoyed for several years your service but this is unprofessional. I know you are probably not even aware of this and that this is not the place for this, but you should have venues to solve problems like this.
Do you know any particular hack/solution to overcome waking up at night at about 1-3 am? Most of the time I fall asleep very quickly, then I wake up after the first or second sleep cycle. Usually, I don't feel tired after and it is really hard to fall back to sleep. It takes much time for me to feel tired again and fall back to sleep again, but even when I can I have a lighter sleep. According to your sleep report, I have lower-than-average risk for insomnia-like symptoms.
A few other observations on top of my first message, My Oura is tracking a -5-8 dip in BPM at the moments I wake up (~2am, ~3:30, sometimes midnight). When I had a Fitbit it tracked a -7-10% dip in oxygen (Pulse Ox) around those same times (before megadosing D). With the D+licorice interaction I had super high and sensitive BPM during the day, so that still points me to aldosterone/etc imbalance. But are these ox/BPM dips related? Are they just sleep apnea? But if so, why at very specific times? I've been looking into trying nitric oxide supplementation but am not sure if it fits this picture?
I've gotten myself into an odd situation with Vitamin D so bear with me please. I've been chronically deficient (VDR SNPs confirmed, maybe absorption issues too?) so I feel I need to supplement for life, but I'd been neglecting it for years because no doctor prioritized it. So last October - November I megadosed 25k-70k daily for a few weeks to force my levels into optimal range (D3 + 3 Ks was most effective) , mainly because I was in pursuit of resolving a severe, chronic cluster of health issues: 1-3-day-long, post-meal "hangovers" involving lethargy, cognitive impairment, eye pain / uveitis, loss of appetite, and mood issues (which I'd asked you about a couple months ago too). I got a blood test and overshot it of course (196 ng/mL of 25OH with calcitriol at 80pg), yet had ZERO negative side effects. This megadosing experiment DID IMPROVE those symptoms which had not responded to anything else for three years, and then completely disappeared like a miracle with slippery elm! (So clearly there was a gut-immune connection; I found your Tregs article which seems relevant). HOWEVER, to try supporting my continuing adrenal/HPA fatigue. I experimented with about 3 days of licorice root/tea at the end of my megadosing phase and my blood pressure skyrocketed to scary levels. I took myself to MedExpress, before connecting the dots: stopping D immediately lowered the high daytime BP. But I was left in a pattern of 3am awakenings for months, finally resolved a few weeks ago with 3000mg (3x) Seriphos and eating glucose Extend bars before bed. (My hunger/metabolism is through the roof, along with shaky body temp / temp sensitivity) Then recently, some of those "hangover" symptoms popped back up. I connected the dots to being 4 months off D, so I took 45k again across two days. Maybe it was too much? Because my sleep has been disturbed with 2am AND 3-4am high BP awakenings, where I can't fall back to sleep after the second awakening. I finally realized this is more likely aldosterone than cortisol? This BP is very 'calm but heavy', whereas cortisol BP always had a clear physical-mental-emotional stress associated with it and responded to Seriphos. My 3x Seriphos before bed has lost its efficacy with this non-stress BP. Taking another 1x with the second awakening might be helping me get back to sleep 2-3 hours later, but also wipes out my morning cortisol/oomph. So. What body equilibrium/system involving D/aldosterone/cortisol/adrenals/electrolytes did licorice screw with, that taking D is producing aldosterone-based insomnia? What am I missing? Based on two blood tests 45 days apart, my 196 levels dropped to 78 at a rate of losing ~2.4ng / day, so I don't think I can go too long with out D. But it's like I traded severe gut-immune symptoms for crazy insomnia, and there's a balance in between that I'm missing and don't know how to get back to. I feel like if I'd never experimented with licorice (the one thing I didn't research enough in my whole life!!!), then the combo of D + slippery elm + glucose management + Seriphos would've supported all of my issues and left me in a good place. Eager for your insight. Thank you.
I was wondering if I could schedule an appointment with you. Brain fog has become a big part of my life, and it's really made working difficult. My forehead always feels tight and it has become very hard to concentrate. I've been trying to treat my brain fog but so far it has been to no avail. Any help would be immensely appreciated.
My DHEA is high, I don't take supplements. I can find lots of info about low DHEA but not high. What are the implications of having a high DHEA the blood test results came back saying 7.14 umol/L out of range
Any particular reason why NAC isn't in your regimen?
Do you have any advice on weaning off from Otrivine for someone who suffers allergic nasal congestion at night?
"HLA-DQ8 even without HLA-DQ2 still seems to confer a 5-10% risk of celiac disease. It seems that selfdecode does not report this risk as below ... ""rs7454108 tags the HLA-DQ8 haplotype"" https://www.snpedia.com/index.php/Celiac_disease ""DQ8-positive HLA-DQA1*03 and HLA-DQB1*0302 5%-10%"" https://www.ncbi.nlm.nih.gov/books/NBK1727/ ""rs7454108 is not linked to any genes. Your genotype is TT"" https://selfdecode.com/snp/rs7454108/ Am I missing something? Kind regards from New Zealand :)"
I just wrote in a question about RA/Carnivore. I meant to also write I am APOE 3/4 so how do I address the saturated fat issue? Thanks.
I am somewhere on the arthritis spectrum, possibly RA (it's painful and in all matching joints). Last summer I went carnivore which helped a ton, but a simultaneous large increase in a calcium supplement gave me C-Diff. My joint pain is unmanageable and I want to carefully return to as close to carnivore as possible. I think I need to keep some level of carb because I have Hashimotos and sleep/ feel better with it. Can you suggest how I would best do this? Soaked rice over vegetables? I've tried everything else- AIP, Keto, Paleo and the arthritis stays with me. Any other suggestions?

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