WELCOME TO THE SELFHACKED VIP AREA

Blog

Dashboard

PAST WEBINARS

    VIP #46                                                                                         Apr 27, 2021

Want to Follow Along?

Click here to see questions answered in webinar

Ask Joe

Have a question that hasn’t been answered in this webinar? Ask Joe yourself and have it answered in an upcoming webinar

ASK JOE

Question
I would like to increase my mitochondrial health. What can I look at?
I eat an animal based diet with lots of meat, organ meat, fish. I also eat fruits and vegetables (no nightshades) and sweet potatoes. No grains and processed foods. What supplements should I take eating this diet? Does this diet miss some critical nutrient my body needs? I can't test all the vitamins and minerals because it's too expensive
Do you believe all people with autoimmune disease have a leaky intestinal barrier? How autoimmunity starts? And if the cause is a "leaky gut" and t-cells reacting to things that should stay inside the gut then why some people get autoimmunity in the thyroid, some in the pancreas, some in the gut, some in the nerves, some in the brain ecc? If the cause is molecular mimicry (immune system getting confused because the protein it attacks are similar to body parts) then shouldn't we all have autoimmunity in the same organ/tissue? Instead some have autoimmunity in the brain (different parts), some in the thyroid, some in the gut, some in the pancreas, some in the joints, some in nerves, some everywhere (systemic) ecc. It seems to me something doesn't add up with this theory. What do you think is the reason we all autoimmunity in different tissues?
Hi Joe, I recently had my DNA analysis completed. One of the supplements that it advised me to consider taking is L-Methylfolate in regard to MTHFR report. However, if you have cancer (which I do) this increases the AA Methionine which essentially feeds cancer! Can you think of anything else that may be worth considering to help me work around increasing Methionine? Thank you!
Does taking methylprednisolone (short term) decrease th1/th17 cells and improve inflammation and autoimmunity symptoms? Is it dangerous to take it short term (like 16mg per day for a week and then taper off gradually)?
What are some of the worst genes correlated with brain fog and inflammation? You mentioned the CNR1, SOD2 and MTHFR...can you mention others?
hey joe,do you still do good if you dont consume carbs like honey and RS? and is your diet mainly meat? how does it look like? and did your issues go away completely with the LAD? like brain fog and cognitive problems? I'm in the same boat as you.
Joe, Could you help answer a couple of questions? 1. I got my test results back and did see a few Wellness Reports. However, the MTHF report is not available for me to purchase. Why aren't my test results covering this report? 2. In your daily routine PDF file, you indicated that you will provide the brand name of the CBD oil you take. But I don't see the information there. Could you let me know where you get yours and what it is? If you rotate a few different kinds, please share. Thank you.
My DNA samples were processed by Ancestry.com. The file available to down load is a csv and it is so large it crashes every single time I try to upload to Self Hacked. Any tips on getting my data uploaded so I can run the SelfHacked analysis?
hey, joe, you mentioned that you stopped taking butyrate, I remember you used to take the life source resistant starch, was that not good for you or you can't get those in Israel?
trying to improve my mitichondrial health I supplemented with D-Ribose L-carnitine and coq10. All of them were not good to me. D ribose and coq10 created crazy palpetations and L-carnitine created hipothyroid. What does it say about my health?
1.. wha do you do to improve immunity to shredding of those who took the vax.
Do have suggestions for restless leg syndrome that happens during the day more so at than night. Thanks
Can you meet all your nutritional needs with whole food plant based diet - no meat, dairy, etc.?
could you share which sleep monitoring app/ machine that you use?
I am highly sensitive to salicylates, additives and dyes (my SelfDecode genetic info. confirms what my body has already told me for years (my throat closes when I am in contact with salicylates via food, the air and my skin). I also (per SelfDecode) have a terrible longevity prognosis due to a poor genetic ability to deal with toxins and high risk cardiovascular genes. My body is breaking down, and I need antioxidants, but as I understand it, the main way to get those is through foods and supplements that are high in salicylates. Is there anything I can do?
What could be the reason for high B6 in blood tests and could it contribute to nuralgia in leg?
Will you please do a webinar on mrna vaccines and the various potentiality for human biological & genetic effects.
also could you talk about how to increase your deep sleep?
can you take CBD and Melatonin togehter?
Considering that our genetics change throughout time, do you recommend getting a 2nd genetic test done in the event that we develop new, chronic health issues to check for genetic mutations, ertc?
does bioidentical estrogen and progesterone increase TGF Beta 1
Where does someone get labs for vitamins, minerals & amino acids?
Can d ribose increase Alzheimer’s risk. I have read studies that indicate a risk
CDPcholine - with food or before?
what type of magnesium do you recommend for sleep and constipation?
Everything changes, why wouldn't DNA? Telomeres, retrovirus’
Do you think the hair analysis is reliable? I tested one and it seemed spot on and was very inexpensive.
Are there any genetic snips that predispose people to Restless Legs syndrome?
D-ribose can raise glucose, which is a risk in Alzheimers. Insulin resistance and high glucose raise risk of Alzheimers.
What causes low white blood cell totals from someone who doesn’t get sick?
Can you talk about the CAT variants and do you rx catalase for it?
Where to locate high-quality practitioners?
My white blood cell count has been low for 8 years but no sickness and feel good. How can I build it up?
Mostly stopped getting sick about 10 yrs ago when I pumped up my D3!

PAST WEBINARS

 VIP #46                                                         APR 27, 2021

Question
Final note to my big questions below: I think it was vitamin K (K1, MK4, MK7) causing my BP issues!? I'm starting to take 10k D without any K. PS: What's the Group Consult for?
I have tried several times to unsubscribe from VIP service but you keep charging me. I have evidence from many emails and only one response. I really enjoyed for several years your service but this is unprofessional. I know you are probably not even aware of this and that this is not the place for this, but you should have venues to solve problems like this.
Do you know any particular hack/solution to overcome waking up at night at about 1-3 am? Most of the time I fall asleep very quickly, then I wake up after the first or second sleep cycle. Usually, I don't feel tired after and it is really hard to fall back to sleep. It takes much time for me to feel tired again and fall back to sleep again, but even when I can I have a lighter sleep. According to your sleep report, I have lower-than-average risk for insomnia-like symptoms.
A few other observations on top of my first message, My Oura is tracking a -5-8 dip in BPM at the moments I wake up (~2am, ~3:30, sometimes midnight). When I had a Fitbit it tracked a -7-10% dip in oxygen (Pulse Ox) around those same times (before megadosing D). With the D+licorice interaction I had super high and sensitive BPM during the day, so that still points me to aldosterone/etc imbalance. But are these ox/BPM dips related? Are they just sleep apnea? But if so, why at very specific times? I've been looking into trying nitric oxide supplementation but am not sure if it fits this picture?
I've gotten myself into an odd situation with Vitamin D so bear with me please. I've been chronically deficient (VDR SNPs confirmed, maybe absorption issues too?) so I feel I need to supplement for life, but I'd been neglecting it for years because no doctor prioritized it. So last October - November I megadosed 25k-70k daily for a few weeks to force my levels into optimal range (D3 + 3 Ks was most effective) , mainly because I was in pursuit of resolving a severe, chronic cluster of health issues: 1-3-day-long, post-meal "hangovers" involving lethargy, cognitive impairment, eye pain / uveitis, loss of appetite, and mood issues (which I'd asked you about a couple months ago too). I got a blood test and overshot it of course (196 ng/mL of 25OH with calcitriol at 80pg), yet had ZERO negative side effects. This megadosing experiment DID IMPROVE those symptoms which had not responded to anything else for three years, and then completely disappeared like a miracle with slippery elm! (So clearly there was a gut-immune connection; I found your Tregs article which seems relevant). HOWEVER, to try supporting my continuing adrenal/HPA fatigue. I experimented with about 3 days of licorice root/tea at the end of my megadosing phase and my blood pressure skyrocketed to scary levels. I took myself to MedExpress, before connecting the dots: stopping D immediately lowered the high daytime BP. But I was left in a pattern of 3am awakenings for months, finally resolved a few weeks ago with 3000mg (3x) Seriphos and eating glucose Extend bars before bed. (My hunger/metabolism is through the roof, along with shaky body temp / temp sensitivity) Then recently, some of those "hangover" symptoms popped back up. I connected the dots to being 4 months off D, so I took 45k again across two days. Maybe it was too much? Because my sleep has been disturbed with 2am AND 3-4am high BP awakenings, where I can't fall back to sleep after the second awakening. I finally realized this is more likely aldosterone than cortisol? This BP is very 'calm but heavy', whereas cortisol BP always had a clear physical-mental-emotional stress associated with it and responded to Seriphos. My 3x Seriphos before bed has lost its efficacy with this non-stress BP. Taking another 1x with the second awakening might be helping me get back to sleep 2-3 hours later, but also wipes out my morning cortisol/oomph. So. What body equilibrium/system involving D/aldosterone/cortisol/adrenals/electrolytes did licorice screw with, that taking D is producing aldosterone-based insomnia? What am I missing? Based on two blood tests 45 days apart, my 196 levels dropped to 78 at a rate of losing ~2.4ng / day, so I don't think I can go too long with out D. But it's like I traded severe gut-immune symptoms for crazy insomnia, and there's a balance in between that I'm missing and don't know how to get back to. I feel like if I'd never experimented with licorice (the one thing I didn't research enough in my whole life!!!), then the combo of D + slippery elm + glucose management + Seriphos would've supported all of my issues and left me in a good place. Eager for your insight. Thank you.
I was wondering if I could schedule an appointment with you. Brain fog has become a big part of my life, and it's really made working difficult. My forehead always feels tight and it has become very hard to concentrate. I've been trying to treat my brain fog but so far it has been to no avail. Any help would be immensely appreciated.
My DHEA is high, I don't take supplements. I can find lots of info about low DHEA but not high. What are the implications of having a high DHEA the blood test results came back saying 7.14 umol/L out of range
Any particular reason why NAC isn't in your regimen?
Do you have any advice on weaning off from Otrivine for someone who suffers allergic nasal congestion at night?
"HLA-DQ8 even without HLA-DQ2 still seems to confer a 5-10% risk of celiac disease. It seems that selfdecode does not report this risk as below ... ""rs7454108 tags the HLA-DQ8 haplotype"" https://www.snpedia.com/index.php/Celiac_disease ""DQ8-positive HLA-DQA1*03 and HLA-DQB1*0302 5%-10%"" https://www.ncbi.nlm.nih.gov/books/NBK1727/ ""rs7454108 is not linked to any genes. Your genotype is TT"" https://selfdecode.com/snp/rs7454108/ Am I missing something? Kind regards from New Zealand :)"
I just wrote in a question about RA/Carnivore. I meant to also write I am APOE 3/4 so how do I address the saturated fat issue? Thanks.
I am somewhere on the arthritis spectrum, possibly RA (it's painful and in all matching joints). Last summer I went carnivore which helped a ton, but a simultaneous large increase in a calcium supplement gave me C-Diff. My joint pain is unmanageable and I want to carefully return to as close to carnivore as possible. I think I need to keep some level of carb because I have Hashimotos and sleep/ feel better with it. Can you suggest how I would best do this? Soaked rice over vegetables? I've tried everything else- AIP, Keto, Paleo and the arthritis stays with me. Any other suggestions?

Ask Joe

Have a question that hasn’t been answered in this webinar? Ask Joe yourself and have it answered in an upcoming webinar

ASK JOE

Cancel Membership?

To cancel your membership, email us at [email protected]