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    VIP #45                                                                                         Mar 23, 2021

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What doctors mean when they say we can change our gene expression? Does that mean I can change a gene to behave like AA/AG instead of GG? Or does that mean some genes can get turned on and off? For example I now have lots of food sensitivities but some years ago I could eat all kind of foods and I was perfectly healthy. What changed? Does gene expression played a role? And if yes can I re-change my gene expression and turn off the genes that are now causing problems? Or is the process only work in a negative way (ie bad genes once turned on they stay like that forever but good genes can get turned off if we have unhealthy habits). Thanks
Hey Joe, wanted to ask another question which is correlated to my last one. Since I have so many genes that impact autophagy negatively (ATG16L1, LRRK2, CLEC16A and others) I'd like to know what are the strongest things that increase autophagy. Both drugs and lifestyle factors, thanks!
hey Joe, I have problems with the LRRK2 gene. Many of the rs are correlated with Parkinson Disease. On selfdecode the rs34637584 seems to be the most correlated with the disease and I don't have the risk variant for this rs (I'm GG). But I have the genetic variants of rs1491942 (GG) and rs76904798 (TT). Do these two rs carry the same risk as the rs34637584 or each rs confer its own independent risk (some lower, some higher risk)?
Does taking inulin (prebiotic) raises butyrate? How do you use Hi-Maize and can you link your source of it? Many thanks!
Hey! Are you still using the Vielight Neuro Duo? Do you find it effective? Personally I'm not noticing much at all if I'm not following an anti inflammatory diet such as the Lectin Avoidance Diet (or strict Carnivore which in my case works even better). It seems like it complements the diet but alone it's not much use. In my case the elimination diet is what helped me the most (like 80%) and the rest (Vielight, Red Light Panel, ICES M1, Meditation, Cold showers, Physical exercise, Sun, Supplements) are just 20% of my recovery. The other question is: do you think that after years on a strict diet our immune system and genetic expression can change so that we can go back eating a "normal" diet without experiencing symptoms? For normal I don't mean junk food everyday....I like eating healthy, but eating normally (gluten included) in the weekend, or on holidays and things like that so that our social life isn't impacted so much.
Hi! I have opposite reaction to medicine. Example Adderall knocks me out for 23hrs. Serious example: 1st time tried very small microdose of weed wax for back pain and was admitted to hospital with uncontrollable, severe myoclonic jerking for 15hrs straight. All docs only note "sensitive" without testing why. After years of frustration, I researched and requested any cytochrome P450 test they could order. My PCP's system could only order Cytochrome P450 2C19 and CYP2D6. Allergy/Immunologist could only order 3A4/3A5. Both don't know how to read results and genetics clinic keeps refusing me, even with referral. Can you tell me what do these results mean? Results 1: Intermediate metabolizer CYP2C19*1/ CYP2C19*2 Results 2: Heterozygous positive for the CYP2D6*4 Null Variant "this patient may be positive for rare CYP2D6 variants not examined." Results 3: CYP3A4 Genotype: *1/ *22 and CYP3A5 Genotype: *1/ *3 Hopefully I can get the full cytochrome super family testing. Is that something you'll be doing? If I'm a poor metabolizer of drugs, should I be concerned of Covid vaccines? Thank you!
Hey Joe what do you think about the JAK2 gene? I'm the unlucky carrier of the CC alleles in the rs10758669. I believe this gene is one of the most problematic for me. I have lots of systemic inflammation including very bad brain fog and only a very restrictive diet (such as carnivore) can put me into total remission. Gluten in particular trigger my symptoms like nothing else despite the fact I don't carry the HLA-DQ genes and I have had two negative endoscopies for celiac disease and negative antibodies to gliadin (IgA and IgG) and transglutaminase 2 but borderline for transglutaminase 6 (the one expressed in the brain). Eliminating gluten improve my symptoms but it's not enough to feel good and productive. I need a much more restrictive diet. The lectin avoidance diet works for me despite the fact I don't carry the CNR1 bad alleles (the entire gene is all green). Do you think that the Jak2 gene alone can cause so many problems? The other problematic gene (homozygous) I carry is the ETS1 which is related to wheat sensitivity but I believe the Jak2 is the most problematic for inflammation and gut permeability. In my recommendations it's written this gene can be ameliorated by supplementing with Omega 3 and drinking green tea. I tried doing that but it doesn't seem to change much. I know there are some drugs that inhibit this gene (Jak2 inhibitors). Do you think they can help? Thanks a lot
Hello, what do you think are the three best strains of bacteria/probiotics for people with inflammation/autoimmunity? I'm experimenting with VSL3 right now, it has a huge amount of bacteria (450 billions per sachet) but I don't know if the strains in it are the most beneficial. It's been only two days since I start taking it so it's too early to tell if it's working
Hey Joe! I have a question about vaccines. There is now a global push to get as many people as possible to get vaccinated against Covid but vaccines stimulate the immune system and I read on Pubmed that they induce a robust Th1/Th17 response and such Th17 cells are maintained long term. For people like me who suffer from an (undiagnosed) systemic autoimmune disease this can be very dangerous and I'm trying to do my best to balance my immune system limiting Th17 cells and increasing T-Reg cells. I believe that stimulating the immune system for us has detrimental consequences but it's not talked about in the media. It seems like they only care about reaching herd immunity as quickly as possible so they can open up and "save" the economy without caring that some people may get nasty consequences with vaccines. What's your take on this? I believe that both viruses (infections) and vaccines have the potential to trigger autoimmunity in susceptible individuals. When I hear stories about people with long term symptoms after contracting the Covid (especially brain fog and fatigue) I believe the virus triggered autoimmune symptoms in those people. A vaccine can potentially do the same because it also stimulate the immune system. Please shed some light on it, thanks.
Hi Joe. First, love this service! I have Meniere's Disease and have had my DNA decoded with you and have implemented the suggestion based on several reports. I've also tried every biohacked and alternative treatment out there currently. Have you worked with anyone with this affliction before and if so, have any suggestions or success stories?
how do i optimize the anti-aging supplements i take? that is, how do i select those that have an optimal effect on me, given my dna?
Hi Joe, I like your new service of offering lab tests for sale. But a problem is there are many tests that it does not have. For example this one https://www.ultalabtests.com/shop/items/item/c-peptide-response-to-glucose-6-specimens So I have a suggestion that could make your service better, how about taking every test at Ulta Lab Tests and offering the same list of tests that they have?
Hello, I have downloaded my raw data from Ancestry.com and would like to forward it to you to analyse re health and wellness. How do I do that please? Also do I still have to pay a fee for this service on top of the membership fee of $99. Thank you
Joe, what brand and type of CBD or THC oil do you take orally on a daily basis?
Could you talk about the CYTH1 (AG) and do you have any recommendations for that?
Are there any genetic expression that would prevent Accutane from being effective?
Do you know about EoE (Eosinophilic esophagitis)? Main symptom is constant clearing of the throat. Is it genetic or food or gut related? Recommended testing, genetic or otherwise?
What are some of the best biological age test kits?
5htp long term can lead to depletion of dopamine, so might want to add Bacopa as well
What diet items lower serotonin?
Joe, what do you think about using Silica to detox?
The library in the back ground is at Trinity College in Dublin, Ireland! I have been there.
will taking activated charcoal and seeing if it helps me tell me if I have heavy metal toxicity.
after bad experience with various SSRIs I moved my son to 5-htp instead. The outcome was great as we seemed to get the desired effect wrt anxiety, depression, mood, brain fog etc. I wanted to get an opinion on whether 5htp is a good long term replacement and whether there are things to watch out for with prolonged use ? Also make sure it doesnt cause some other issue...
I experience gut, brain fog, insulin resistance, and mood issues. In my CNR1 report, I have recommendations to both increase and decrease my CNR1 activity. Should I be trying to increase or decrease activity since in mice lack of CB1 means less insulin resistance (so reduce CNR1 activity), but increased activity could help resolve gut inflammation? How can you need to both increase and decrease activity at the same time?

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 VIP #45                                                         MAR 23, 2021

Question
Final note to my big questions below: I think it was vitamin K (K1, MK4, MK7) causing my BP issues!? I'm starting to take 10k D without any K. PS: What's the Group Consult for?
I have tried several times to unsubscribe from VIP service but you keep charging me. I have evidence from many emails and only one response. I really enjoyed for several years your service but this is unprofessional. I know you are probably not even aware of this and that this is not the place for this, but you should have venues to solve problems like this.
Do you know any particular hack/solution to overcome waking up at night at about 1-3 am? Most of the time I fall asleep very quickly, then I wake up after the first or second sleep cycle. Usually, I don't feel tired after and it is really hard to fall back to sleep. It takes much time for me to feel tired again and fall back to sleep again, but even when I can I have a lighter sleep. According to your sleep report, I have lower-than-average risk for insomnia-like symptoms.
A few other observations on top of my first message, My Oura is tracking a -5-8 dip in BPM at the moments I wake up (~2am, ~3:30, sometimes midnight). When I had a Fitbit it tracked a -7-10% dip in oxygen (Pulse Ox) around those same times (before megadosing D). With the D+licorice interaction I had super high and sensitive BPM during the day, so that still points me to aldosterone/etc imbalance. But are these ox/BPM dips related? Are they just sleep apnea? But if so, why at very specific times? I've been looking into trying nitric oxide supplementation but am not sure if it fits this picture?
I've gotten myself into an odd situation with Vitamin D so bear with me please. I've been chronically deficient (VDR SNPs confirmed, maybe absorption issues too?) so I feel I need to supplement for life, but I'd been neglecting it for years because no doctor prioritized it. So last October - November I megadosed 25k-70k daily for a few weeks to force my levels into optimal range (D3 + 3 Ks was most effective) , mainly because I was in pursuit of resolving a severe, chronic cluster of health issues: 1-3-day-long, post-meal "hangovers" involving lethargy, cognitive impairment, eye pain / uveitis, loss of appetite, and mood issues (which I'd asked you about a couple months ago too). I got a blood test and overshot it of course (196 ng/mL of 25OH with calcitriol at 80pg), yet had ZERO negative side effects. This megadosing experiment DID IMPROVE those symptoms which had not responded to anything else for three years, and then completely disappeared like a miracle with slippery elm! (So clearly there was a gut-immune connection; I found your Tregs article which seems relevant). HOWEVER, to try supporting my continuing adrenal/HPA fatigue. I experimented with about 3 days of licorice root/tea at the end of my megadosing phase and my blood pressure skyrocketed to scary levels. I took myself to MedExpress, before connecting the dots: stopping D immediately lowered the high daytime BP. But I was left in a pattern of 3am awakenings for months, finally resolved a few weeks ago with 3000mg (3x) Seriphos and eating glucose Extend bars before bed. (My hunger/metabolism is through the roof, along with shaky body temp / temp sensitivity) Then recently, some of those "hangover" symptoms popped back up. I connected the dots to being 4 months off D, so I took 45k again across two days. Maybe it was too much? Because my sleep has been disturbed with 2am AND 3-4am high BP awakenings, where I can't fall back to sleep after the second awakening. I finally realized this is more likely aldosterone than cortisol? This BP is very 'calm but heavy', whereas cortisol BP always had a clear physical-mental-emotional stress associated with it and responded to Seriphos. My 3x Seriphos before bed has lost its efficacy with this non-stress BP. Taking another 1x with the second awakening might be helping me get back to sleep 2-3 hours later, but also wipes out my morning cortisol/oomph. So. What body equilibrium/system involving D/aldosterone/cortisol/adrenals/electrolytes did licorice screw with, that taking D is producing aldosterone-based insomnia? What am I missing? Based on two blood tests 45 days apart, my 196 levels dropped to 78 at a rate of losing ~2.4ng / day, so I don't think I can go too long with out D. But it's like I traded severe gut-immune symptoms for crazy insomnia, and there's a balance in between that I'm missing and don't know how to get back to. I feel like if I'd never experimented with licorice (the one thing I didn't research enough in my whole life!!!), then the combo of D + slippery elm + glucose management + Seriphos would've supported all of my issues and left me in a good place. Eager for your insight. Thank you.
I was wondering if I could schedule an appointment with you. Brain fog has become a big part of my life, and it's really made working difficult. My forehead always feels tight and it has become very hard to concentrate. I've been trying to treat my brain fog but so far it has been to no avail. Any help would be immensely appreciated.
My DHEA is high, I don't take supplements. I can find lots of info about low DHEA but not high. What are the implications of having a high DHEA the blood test results came back saying 7.14 umol/L out of range
Any particular reason why NAC isn't in your regimen?
Do you have any advice on weaning off from Otrivine for someone who suffers allergic nasal congestion at night?
"HLA-DQ8 even without HLA-DQ2 still seems to confer a 5-10% risk of celiac disease. It seems that selfdecode does not report this risk as below ... ""rs7454108 tags the HLA-DQ8 haplotype"" https://www.snpedia.com/index.php/Celiac_disease ""DQ8-positive HLA-DQA1*03 and HLA-DQB1*0302 5%-10%"" https://www.ncbi.nlm.nih.gov/books/NBK1727/ ""rs7454108 is not linked to any genes. Your genotype is TT"" https://selfdecode.com/snp/rs7454108/ Am I missing something? Kind regards from New Zealand :)"
I just wrote in a question about RA/Carnivore. I meant to also write I am APOE 3/4 so how do I address the saturated fat issue? Thanks.
I am somewhere on the arthritis spectrum, possibly RA (it's painful and in all matching joints). Last summer I went carnivore which helped a ton, but a simultaneous large increase in a calcium supplement gave me C-Diff. My joint pain is unmanageable and I want to carefully return to as close to carnivore as possible. I think I need to keep some level of carb because I have Hashimotos and sleep/ feel better with it. Can you suggest how I would best do this? Soaked rice over vegetables? I've tried everything else- AIP, Keto, Paleo and the arthritis stays with me. Any other suggestions?

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