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    VIP #44                                                                                         Feb 26, 2021

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Question
Hello Joe, Can you suggest a biohack/ work around for the ABCG5 gene/ super absorber of phytosterols - short of zetia and low dose statin?
Are there any biomarkers of neuroinflammation? I have read that there are none, because it is intracellular. I suffer from CFS due to an unidentified infection, and my brain often feels hammered. My CRP is next to zero.
Can arterial plaque be reveresed , I suffer from primary aldosteronism looking to have that figured out but would like to know how to reverse the existing plaque in the arteries , thank Joe!
Hi Joe, Im not sure if this is a question you ca answer but I will ask anyway I am on dexamphetamine for ADHD, Through my own research I have discovered it raises plasma cortisol, I have quite low cortisol under range, but took synatchen test which I passed, my question is would this make the synatchen test fasle positive as the HPA axis with the dex created this cortisol to go higher, I know its a CNS drug that effects the HPA but having dificulty understanding if what it produces is cortisol that can keep you alive in stress? or is it CBG that wont save life. The doctors , specialists do not seem to know much about this and I feel its masking an adrenal insufficiency problem. ? Have you got anything on genetics for Addisons Thank you
Hi Joe, will you offer findings on genetic mutations and hereditary diseases? I think it can be very helpful to identify any hereditary diseases that can potentially transfer to an offspring and help some of us to plan accordingly.
What is a recommended set of supplements to promote good sleep during the night? What is a recommended set of supplements to promote good energy during the day?
I am still wanting more explanation about the COMT report. I received the explanation that the results are based on the gene combination but not the why of each and how that works. Thanks
Hi Joe, there are certain foods in my diet that consistently cause bloat (I'm looking at you, strawberries), but that have a desirable nutritional profile. I'm not sure if I should consider the bloat as my body telling me to stay away, or, so long as I'm not too uncomfortable, just ignore it so I can enjoy the nutritional benefits. Whatcha think?
I have a mutation 5376AA, oxytocin. Would you have any idea how this might affect a person desiring children, having relationships with people in general, one's personality toward people. Thanks.
Hello, Joe, I didin't find any infos in your videos about POTS(postural orthostatic tachicardyia), do you know some natural (or not) supplement for this condition? Especialy about hyperadrenergic pots.
Recently, I've read the RDA requirements for Vit D are too low and are actually much higher than are recommended. Since I don't want to run into Vit D toxicity issues, I want to be taking the right amounts of Vit K. What would be the proper ratio of Vit D to K? The second half of my question is, is it possible that someone with autoimmunity would notice a benefit from higher Vit D levels, than someone without autoimmunity?
-joe I get some gas not a lot and I’m currently eating just meat right now with fat, what could that mean?
-joe would you recommend trying to introduce supplements from my reports like mood and cognition after I get my diet in order and let my gut heal, and then start the supplements? Also did you start taking supplements when you were not inflamed like when you got you deit in order and the. You started the supplements for mood and cognition? If you are inflamed or deit isn’t good then the supplements woudnt do you any good right?
-joe I have checked my food sensitivities report and it shows I’m lactose intolerant and sensitive to food additives. But dosent say anything about lectins or carbohydrates or gluten, yet when I eat anything other than meat like chicken beef and fish, I get inflammation. I am currently doing LAD but wanted to ask if you have came across people that don’t have the bad genes and are still sensitive? Also do you think this could be a leaky gut issiue and if so what would you advice moving forward to tackle it? Should I eat foods i don’t react to and then let me gut heal and then reintroduce them after or what would be a good way to go about it?
joe i am getting dry skin on a meat-based diet anything you suggest also less sun cause live up north and its winter?
joe when you eat inflammatory foods to you do you get inflamed instantly?
During last zoom session, you mentioned that you are drinking Reishi tea and it helped to increase your Deep Sleep (oura). My average deep sleep is 40minutes and have never had over 1.5hrs. I bought the four sigmatic reishi powder and have been drinking it every evening. The very first night, I immediately felt extremely sleepy, on subsequent days it has produced significantly less sleepiness. Unfortunately, reishi hasn't increased my deep sleep, do you have anything else in your sleep stack that is helping you get 3-4 hours?
Hi Joe, Is there a possibility that Selfhacked will create a report on optimal foods based on your genes? Thanks!!
hey joe, after the LAD diet my inflamed went down and my brain fog also went down, but I am still not clear-headed, I still have this low-grade chronic fig and inflam I feel all the time, what do you think it could be and how can I go about to combat it? mitochondria supps? llt/ices? or oxygen therapy?
hey joe, do you think it would be smart to microdose with psilocybin? if my diet is good and my sleep but still have some bf and mood issues and slow brain after TBI? also when i sleep less or sleep late and wake up early my brain fog and mood are good the next day what would that mean?
Squamous cell cancer acts very differently in different places in the body; is there DNA indication of the kind of cancer one might be prone to getting wherever it is? There seems to be a relationship between skin cancer and breast DCI's.
I take Korean Ginseng for energy boost. It supposedly reduces the reverse T3.
Should raw fruits and vegetables be consumed sparingly? They are good, but that easy to digest.
Any comments on the research into cell senescence and autophagy to help with cell repair and other genetic up- and down- regulation?
Can you confirm if a person is on a blood thinner that they should NOT or they CAN use vitamin K2. I know K1 is contraindicated.
is 5htp a good substitute to SSRI's ? My experience is it delivers the outcome without the side effects....

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 VIP #44                                                         FEB 26, 2021

Question
Final note to my big questions below: I think it was vitamin K (K1, MK4, MK7) causing my BP issues!? I'm starting to take 10k D without any K. PS: What's the Group Consult for?
I have tried several times to unsubscribe from VIP service but you keep charging me. I have evidence from many emails and only one response. I really enjoyed for several years your service but this is unprofessional. I know you are probably not even aware of this and that this is not the place for this, but you should have venues to solve problems like this.
Do you know any particular hack/solution to overcome waking up at night at about 1-3 am? Most of the time I fall asleep very quickly, then I wake up after the first or second sleep cycle. Usually, I don't feel tired after and it is really hard to fall back to sleep. It takes much time for me to feel tired again and fall back to sleep again, but even when I can I have a lighter sleep. According to your sleep report, I have lower-than-average risk for insomnia-like symptoms.
A few other observations on top of my first message, My Oura is tracking a -5-8 dip in BPM at the moments I wake up (~2am, ~3:30, sometimes midnight). When I had a Fitbit it tracked a -7-10% dip in oxygen (Pulse Ox) around those same times (before megadosing D). With the D+licorice interaction I had super high and sensitive BPM during the day, so that still points me to aldosterone/etc imbalance. But are these ox/BPM dips related? Are they just sleep apnea? But if so, why at very specific times? I've been looking into trying nitric oxide supplementation but am not sure if it fits this picture?
I've gotten myself into an odd situation with Vitamin D so bear with me please. I've been chronically deficient (VDR SNPs confirmed, maybe absorption issues too?) so I feel I need to supplement for life, but I'd been neglecting it for years because no doctor prioritized it. So last October - November I megadosed 25k-70k daily for a few weeks to force my levels into optimal range (D3 + 3 Ks was most effective) , mainly because I was in pursuit of resolving a severe, chronic cluster of health issues: 1-3-day-long, post-meal "hangovers" involving lethargy, cognitive impairment, eye pain / uveitis, loss of appetite, and mood issues (which I'd asked you about a couple months ago too). I got a blood test and overshot it of course (196 ng/mL of 25OH with calcitriol at 80pg), yet had ZERO negative side effects. This megadosing experiment DID IMPROVE those symptoms which had not responded to anything else for three years, and then completely disappeared like a miracle with slippery elm! (So clearly there was a gut-immune connection; I found your Tregs article which seems relevant). HOWEVER, to try supporting my continuing adrenal/HPA fatigue. I experimented with about 3 days of licorice root/tea at the end of my megadosing phase and my blood pressure skyrocketed to scary levels. I took myself to MedExpress, before connecting the dots: stopping D immediately lowered the high daytime BP. But I was left in a pattern of 3am awakenings for months, finally resolved a few weeks ago with 3000mg (3x) Seriphos and eating glucose Extend bars before bed. (My hunger/metabolism is through the roof, along with shaky body temp / temp sensitivity) Then recently, some of those "hangover" symptoms popped back up. I connected the dots to being 4 months off D, so I took 45k again across two days. Maybe it was too much? Because my sleep has been disturbed with 2am AND 3-4am high BP awakenings, where I can't fall back to sleep after the second awakening. I finally realized this is more likely aldosterone than cortisol? This BP is very 'calm but heavy', whereas cortisol BP always had a clear physical-mental-emotional stress associated with it and responded to Seriphos. My 3x Seriphos before bed has lost its efficacy with this non-stress BP. Taking another 1x with the second awakening might be helping me get back to sleep 2-3 hours later, but also wipes out my morning cortisol/oomph. So. What body equilibrium/system involving D/aldosterone/cortisol/adrenals/electrolytes did licorice screw with, that taking D is producing aldosterone-based insomnia? What am I missing? Based on two blood tests 45 days apart, my 196 levels dropped to 78 at a rate of losing ~2.4ng / day, so I don't think I can go too long with out D. But it's like I traded severe gut-immune symptoms for crazy insomnia, and there's a balance in between that I'm missing and don't know how to get back to. I feel like if I'd never experimented with licorice (the one thing I didn't research enough in my whole life!!!), then the combo of D + slippery elm + glucose management + Seriphos would've supported all of my issues and left me in a good place. Eager for your insight. Thank you.
I was wondering if I could schedule an appointment with you. Brain fog has become a big part of my life, and it's really made working difficult. My forehead always feels tight and it has become very hard to concentrate. I've been trying to treat my brain fog but so far it has been to no avail. Any help would be immensely appreciated.
My DHEA is high, I don't take supplements. I can find lots of info about low DHEA but not high. What are the implications of having a high DHEA the blood test results came back saying 7.14 umol/L out of range
Any particular reason why NAC isn't in your regimen?
Do you have any advice on weaning off from Otrivine for someone who suffers allergic nasal congestion at night?
"HLA-DQ8 even without HLA-DQ2 still seems to confer a 5-10% risk of celiac disease. It seems that selfdecode does not report this risk as below ... ""rs7454108 tags the HLA-DQ8 haplotype"" https://www.snpedia.com/index.php/Celiac_disease ""DQ8-positive HLA-DQA1*03 and HLA-DQB1*0302 5%-10%"" https://www.ncbi.nlm.nih.gov/books/NBK1727/ ""rs7454108 is not linked to any genes. Your genotype is TT"" https://selfdecode.com/snp/rs7454108/ Am I missing something? Kind regards from New Zealand :)"
I just wrote in a question about RA/Carnivore. I meant to also write I am APOE 3/4 so how do I address the saturated fat issue? Thanks.
I am somewhere on the arthritis spectrum, possibly RA (it's painful and in all matching joints). Last summer I went carnivore which helped a ton, but a simultaneous large increase in a calcium supplement gave me C-Diff. My joint pain is unmanageable and I want to carefully return to as close to carnivore as possible. I think I need to keep some level of carb because I have Hashimotos and sleep/ feel better with it. Can you suggest how I would best do this? Soaked rice over vegetables? I've tried everything else- AIP, Keto, Paleo and the arthritis stays with me. Any other suggestions?

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