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    VIP #33                                                                                         APR 12, 2019

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Question
Ive gotten result from an Immunology test and for the last year (I take tests every 6 months)my TNF-RI is high. It's 677.30pg/mL..Is there any reason why??Where should my docs look? They think it's coming from my gut and next weekI'm doing a colonscopy as I'm almost 70. I took one at 65 and all was fine. Please comment
I have alot of SNPS and have received recommendations butI am wondering if I need to correct some before others can be correctly effected? Fr example-I am homogyzeous for the FAAH gene and metabolize my own endocannaboids too quickly.However,when I try to supplement with CBD oil -even at very small amounts,I become even more depressed .I find that several SNPS I have(dealing with low mood)in trying the suggested intervention causes a bad reaction. I cannnot take SAM-E(causes extreme anxiet)yet it is also one that is recommended for me.I am having a dfficult time in trying to implement the suggestions due to their effect that goes the opposite f its intended reaction.So should SNPs be dealt with in some type of order when they are causing a problem?Thank you
Hi Joe! Thanks for Apoe diet book and recipes. As I understand the main takeaway for Apoe4 is a mediterranean diet. Which I think is a relatively easy way to stick to. In moderation, there are a lot of things we can consume. However, I think that for an adult man who does systemic training consuming enough calories (more than 2500calories) with this diet is not an easy way. As I understand the high glycemic foods are not good, but these foods have a higher calorie density (Ex. white rice. ). I assume that the problem is not the number of the calories but the higher blood sugar and insulin spike after consuming them? So, are there any ways to partially "hack/mitigate" them with supplement/tools to achive a prelonged absortion time, and in this way lovering the metabolic stress on the body. The second option I think could be a higher amount of protein from plants or plants protein powder, such as pea protein. What do you think about it? Thanks.
Hi what do you suggest for the imsomnio? I already avoid the blue light at night and all kinds of light, probe infusion of valerian, linden, etc. and it does not work. I also have dinner early and I can not sleep. I have no breathing problems. What do you suggest besides avoiding energy drinks in the afternoon and intense sports? thank you.
You just sent out your weekly news and asked for MD' or DO's to sign on to be reviewers which is something I tried to get you to do well over a year ago and you would not have anything to do with me. Today I saw you were asking for volunteers and tried to acces the form and it refuses to let me log on and basically says I am not qualified or at least that I am not a member and I can not do anything without being a member - So that is my first review- fix your newsletter so the doctors can sign up! David Steenblock, DO Do-stemcells.com I have I believe the largest medical library of aany physician in the world which I offered you to use but you did not want to bother. How about 60,000 medical books and over one million organized scientific article?
Hi Joe, Do you have any info regarding Full Body Vibration plates. I have one that I go on for 10 minutes each day. It seems to get all the blood flowing in my body but I am wondering if you know of any studies that have looked into these and see what exactly it is doing.
Hi Joe, I messaged last month re: low iron levels and hemochromatosis; you stated in the webinar call you didn't think low iron levels were right to do. To clarify, it is global health guidelines to get our ferritin levels down to 50-100 (normal male 300) because our scores rise continually due to the lack of iron regulation (the body just lets it in instead of getting rid of excess). So we are stuck with low ferritin, low iron and low hemoglobin, otherwise, iron accumulates in the heart, liver and joints, leading to failure 20-30 years early. My question therefore remains: can we biohack our energy levels in an alternative way (factoring in a low iron profile that cannot be increased, like you would with anemics)? We simply cannot get oxygen round our system with the lack of haemoglobin caused by the low iron. Thanks, Chris
Hi Joe: I am new here. I haven't been able to fully utilize your website but I am hoping you can give me some information. I have immune and histamine issues that I believe are especially affecting my ability to sleep. I recently received my 23andMe results and have two bad copies of the MTHFR gene C677T, two bad copies of MTRR A66G, two bad copies each COMT V158M and COMT H62H. I also have two bad copies of BC01 as well as two bad copies of VDR taq1 and Bsm1. I also two bad copies of APOE variation ARG176Cys. My APOE genotype is APOE3/3. Up until a year ago my life was normal and I was healthy and thriving. I am 62 years old. My 1/2 sister has similar 23andme results. A recent methylation panel indicates that I am not making enough sam-3 and my SAM:SAH result is 3.2 where the methylation reference range is more than 4. Adenosine is 115 where the reference range is 20-80. Somewhere on the internet I found that the H3 receptor activity promotes sleep. I am working with a functional doctor who says my T cell regulation and immune response which leads to histamine overload is very central. I have a benign nodule on my thyroid that is benign. The nodule was more prominent over the summer but is not as large. My thyroid functions normal. I think my methylation status is negatively affecting my sleep and possibly my immune system but I don't know for certain if that is the case. I can fall asleep but only sleep 4 hours at most each night and I really need sleep to heal. I don't nap during the day so that I am very tired when I go to bed. The functional doctor recently gave me 200 mg sam-3 with methylated b cofactors to take twice daily but I had to cut back and eventually stop after 4 weeks as it was causing anxiety. I am tapering from clonazepam that was prescribed for deranged sleep last Sept and am down to .125 mg. I am slowly tapering. My predicted NAT2 acetylator phenotype with probability estimate is slow 0.998731. 23andme does not report on AOC1 (DAO) but I now have a hard time with bone broth and fermented foods, which was not the case in the past. Can you suggest a protocol to help normalize sleep. I am taking supplements to include vitamins A, D, and DHEA. I take a probiotic that does not produce histamine in the gut. I was on a repairvite diet Since Sept and am avoiding dairy and gluten. At night I am taking 200 mg phosphatidylserine and 3-6 mcg of plant based melatonin. Is there some way to work with the H-3 receptor to improve sleep? I think I have too much histamine but probably other things like adrenaline and cortisol that my body can't clear efficiently. I have been doing yoga and meditating to try and reduce stress but the past 10 months have been very stressful because no one knew what was going on with my body. Histamine and especially methylation affects so many body functions. I recently purchased a book by Ben Lynch called Dirty Genes and he speaks to going low and slow with supplementation and only take them when necessary and then stop until they are needed again when trying to balance methylation. My current functional doctor is brilliant but he doesn't have the same ideas and will not consider a second opinion. He says I will need to take sam-e the rest of my life. I have read that it is best to prepare the body by opening pathways. Thanks in advance for your assistance.
Hi Joe,Conditions: Juvenile Myoclonic epilepsy Psoriasis Osteoporosis Reynauds phenomena1. I have Epilepsy, largely controlled using a medium dose of medication... but obviously I want to get off them if possible. i tried CBD oil twice now using different, high quality brands (from the UK) and both times I got no benefits and experienced pretty severe brainfog/clouded thinking and very dark moods within the first day of starting on a small dose and then increasing it slowly? Why could this be? (problem with receptors?)2. Also, I have psoriasis and tested positive for leaky gut using the lactulose/mannitol test in the past (years ago) and have definite food sensitivities to eggs/regular dairy/etc. - so I bought the Cyrex Array #2 to test for LPS/Occludin/Zonulin and Actomysin antibodies, and they all came back well within the normal range. How is it possible to have psoriasis/reynauds phenomenon (autoimmune issues) and multiple food sensitivities if my gut appears to be intact? Are the cyrex tests good or are they inaccurate? Should I order another leaky gut urine test to confirm or deny the cyrex blood result?3. What is the best way to figure out all foods which you are really sensitive to? Are you best off getting some kind of food intolerance blood testing done - ALCAT/Cyrex #10/etc. - or an elimination diet? Also please give some more info about what is included in your elimination diet course as there isn't a very detailed sales page about it.4. I read a lot on your site and love the fact you quote studies... but it is often hard to find details on exactly what quantities of supplements/what exact parameters for treatment were. here are the 2 studies I am particularly interested in: - https://www.ncbi.nlm.nih.gov/pubmed/14643904 (this is the psoriasis study showing 78.8% os psoriasis patients became symptom free after taking bile supplements. But it doesn't give the dose or brand/type of bile used to achieve the results.) - https://www.ncbi.nlm.nih.gov/pubmed/19044219 (this is the study where 25 out of 25 epilepsy patients became seizure free and 75% got off their medications... but I would love to know who did the study/the type of neurofeedback used, etc. so I can get something as near to what worked so well in that study. Is there any way to find out these details?)5. Also, I contacted one neurofeedback place here in the UK and they said because I have psoriasis and reynauds that I should just follow the GAPS diet as my seizures are probably caused by the same mechanism and that neurofeedback would be "fighting my body chemistry" ... this makes no sense to me as my symptoms of skin flare ups and when I feel good/bad in my brain to not tie up... but I just wanted your opinion too.Lastly, if you were to consider creating another course/book/protocol... do oral tolerance step by step. I would buy it.Thanks.
Why does Modafinil give a hangover effect after it wears off? Being a dopamine reuptake inhibitor and not an agonist I'm not expecting for downregulation to happen. Is it tied to its other mechanisms then? Or to nutrient depletion? Also, about dopamine, is it possible for tiny doses of Modafinil (5-10 mg) to give issues such as dopamine hypersensitivity and tardive dyskinesia?
I've been trying out the Ginseng + Ginkgo combo and I like it quite much. Are there any other stacks or single compounds that you would recommend? Possibly with a long half-life, so that they can be used as "core" to which I can optionally add other nootropics.
Hi Joe,Just got back my results from GI map and I have: C. Difficile toxin A and B - elevated Enterotoxigenic E. coli LT/ST - elevated Enterococcus faecalis - elevated Morganella spp. - elevated Pseudomonas spp. - elevated Pseudomonas aeruginosa - elevatedBasically a lot of opportunistic bacteria and pathogens in my gut.Also my SIgA is low at 135 (reference range 510-2010)Is there a regime on your website I should follow. Is this something I should consider using antibiotics for or stick with natural therapies? and do you think this could be related to either psoriasis or epilepsy?Thanks.
What are the best strategies to prevent Modafinil and Nicotine crash?
Sorry Joe, one more question based on my one below about gut infections... what are your thoughts on FMT? (fecal microbial transplant)Thanks.
Hi Joe,Is it safe for people with neurological disorders like epielpsy, depression, MS, etc. where glutamate issues may play a role to take glutamine to help heal the gut lining... or is it best avoided?I'm not sure as they sound very similar! Thanks for any clarification.
Hi Joe, My house has mold and some damp... what is the best test to see if they are causing issues for me body (best tests)?and do you recommend the mercury tri-test for testing if mercury is an issue? (my mother had multiple amalgam fillings and metalwork in her spine)Thanks.
When I tried the Keto diet, my brain felt great and I had great mental clarity ... but I kept on being sick and had really nausea and my psoriasis flared up like crazy, not like the "keto-flu" but this lasted for weeks and got so bad I couldn't carry on with the diet... could this be due to NAFLD or other fat digestion problems?
Hi Joe!I've been battling health issues since three years ago when I got intoxicated by Ciprofloxacin. I've made some health tests recently which has shown: *Low cortisol salivar curve *High DHEA *Low Progesterone *Medium/Low Testosterone *High Estrone/Estradiol I've read that the treatment of choice for low Cortisol is Hydrocortisone, which unfortunately, isn't well tolerated by Fluoroquinolone victims. Is there any reading on SelfHacked or alternative treatment options you know?

PAST WEBINARS

 VIP #33                                                         APR 12, 2019

Question
Ive gotten result from an Immunology test and for the last year (I take tests every 6 months)my TNF-RI is high. It's 677.30pg/mL..Is there any reason why??Where should my docs look? They think it's coming from my gut and next weekI'm doing a colonscopy as I'm almost 70. I took one at 65 and all was fine. Please comment
I have alot of SNPS and have received recommendations butI am wondering if I need to correct some before others can be correctly effected? Fr example-I am homogyzeous for the FAAH gene and metabolize my own endocannaboids too quickly.However,when I try to supplement with CBD oil -even at very small amounts,I become even more depressed .I find that several SNPS I have(dealing with low mood)in trying the suggested intervention causes a bad reaction. I cannnot take SAM-E(causes extreme anxiet)yet it is also one that is recommended for me.I am having a dfficult time in trying to implement the suggestions due to their effect that goes the opposite f its intended reaction.So should SNPs be dealt with in some type of order when they are causing a problem?Thank you
Hi Joe! Thanks for Apoe diet book and recipes. As I understand the main takeaway for Apoe4 is a mediterranean diet. Which I think is a relatively easy way to stick to. In moderation, there are a lot of things we can consume. However, I think that for an adult man who does systemic training consuming enough calories (more than 2500calories) with this diet is not an easy way. As I understand the high glycemic foods are not good, but these foods have a higher calorie density (Ex. white rice. ). I assume that the problem is not the number of the calories but the higher blood sugar and insulin spike after consuming them? So, are there any ways to partially "hack/mitigate" them with supplement/tools to achive a prelonged absortion time, and in this way lovering the metabolic stress on the body. The second option I think could be a higher amount of protein from plants or plants protein powder, such as pea protein. What do you think about it? Thanks.
Hi what do you suggest for the imsomnio? I already avoid the blue light at night and all kinds of light, probe infusion of valerian, linden, etc. and it does not work. I also have dinner early and I can not sleep. I have no breathing problems. What do you suggest besides avoiding energy drinks in the afternoon and intense sports? thank you.
You just sent out your weekly news and asked for MD' or DO's to sign on to be reviewers which is something I tried to get you to do well over a year ago and you would not have anything to do with me. Today I saw you were asking for volunteers and tried to acces the form and it refuses to let me log on and basically says I am not qualified or at least that I am not a member and I can not do anything without being a member - So that is my first review- fix your newsletter so the doctors can sign up! David Steenblock, DO Do-stemcells.com I have I believe the largest medical library of aany physician in the world which I offered you to use but you did not want to bother. How about 60,000 medical books and over one million organized scientific article?
Hi Joe, Do you have any info regarding Full Body Vibration plates. I have one that I go on for 10 minutes each day. It seems to get all the blood flowing in my body but I am wondering if you know of any studies that have looked into these and see what exactly it is doing.
Hi Joe, I messaged last month re: low iron levels and hemochromatosis; you stated in the webinar call you didn't think low iron levels were right to do. To clarify, it is global health guidelines to get our ferritin levels down to 50-100 (normal male 300) because our scores rise continually due to the lack of iron regulation (the body just lets it in instead of getting rid of excess). So we are stuck with low ferritin, low iron and low hemoglobin, otherwise, iron accumulates in the heart, liver and joints, leading to failure 20-30 years early. My question therefore remains: can we biohack our energy levels in an alternative way (factoring in a low iron profile that cannot be increased, like you would with anemics)? We simply cannot get oxygen round our system with the lack of haemoglobin caused by the low iron. Thanks, Chris
Hi Joe: I am new here. I haven't been able to fully utilize your website but I am hoping you can give me some information. I have immune and histamine issues that I believe are especially affecting my ability to sleep. I recently received my 23andMe results and have two bad copies of the MTHFR gene C677T, two bad copies of MTRR A66G, two bad copies each COMT V158M and COMT H62H. I also have two bad copies of BC01 as well as two bad copies of VDR taq1 and Bsm1. I also two bad copies of APOE variation ARG176Cys. My APOE genotype is APOE3/3. Up until a year ago my life was normal and I was healthy and thriving. I am 62 years old. My 1/2 sister has similar 23andme results. A recent methylation panel indicates that I am not making enough sam-3 and my SAM:SAH result is 3.2 where the methylation reference range is more than 4. Adenosine is 115 where the reference range is 20-80. Somewhere on the internet I found that the H3 receptor activity promotes sleep. I am working with a functional doctor who says my T cell regulation and immune response which leads to histamine overload is very central. I have a benign nodule on my thyroid that is benign. The nodule was more prominent over the summer but is not as large. My thyroid functions normal. I think my methylation status is negatively affecting my sleep and possibly my immune system but I don't know for certain if that is the case. I can fall asleep but only sleep 4 hours at most each night and I really need sleep to heal. I don't nap during the day so that I am very tired when I go to bed. The functional doctor recently gave me 200 mg sam-3 with methylated b cofactors to take twice daily but I had to cut back and eventually stop after 4 weeks as it was causing anxiety. I am tapering from clonazepam that was prescribed for deranged sleep last Sept and am down to .125 mg. I am slowly tapering. My predicted NAT2 acetylator phenotype with probability estimate is slow 0.998731. 23andme does not report on AOC1 (DAO) but I now have a hard time with bone broth and fermented foods, which was not the case in the past. Can you suggest a protocol to help normalize sleep. I am taking supplements to include vitamins A, D, and DHEA. I take a probiotic that does not produce histamine in the gut. I was on a repairvite diet Since Sept and am avoiding dairy and gluten. At night I am taking 200 mg phosphatidylserine and 3-6 mcg of plant based melatonin. Is there some way to work with the H-3 receptor to improve sleep? I think I have too much histamine but probably other things like adrenaline and cortisol that my body can't clear efficiently. I have been doing yoga and meditating to try and reduce stress but the past 10 months have been very stressful because no one knew what was going on with my body. Histamine and especially methylation affects so many body functions. I recently purchased a book by Ben Lynch called Dirty Genes and he speaks to going low and slow with supplementation and only take them when necessary and then stop until they are needed again when trying to balance methylation. My current functional doctor is brilliant but he doesn't have the same ideas and will not consider a second opinion. He says I will need to take sam-e the rest of my life. I have read that it is best to prepare the body by opening pathways. Thanks in advance for your assistance.
Hi Joe,Conditions: Juvenile Myoclonic epilepsy Psoriasis Osteoporosis Reynauds phenomena1. I have Epilepsy, largely controlled using a medium dose of medication... but obviously I want to get off them if possible. i tried CBD oil twice now using different, high quality brands (from the UK) and both times I got no benefits and experienced pretty severe brainfog/clouded thinking and very dark moods within the first day of starting on a small dose and then increasing it slowly? Why could this be? (problem with receptors?)2. Also, I have psoriasis and tested positive for leaky gut using the lactulose/mannitol test in the past (years ago) and have definite food sensitivities to eggs/regular dairy/etc. - so I bought the Cyrex Array #2 to test for LPS/Occludin/Zonulin and Actomysin antibodies, and they all came back well within the normal range. How is it possible to have psoriasis/reynauds phenomenon (autoimmune issues) and multiple food sensitivities if my gut appears to be intact? Are the cyrex tests good or are they inaccurate? Should I order another leaky gut urine test to confirm or deny the cyrex blood result?3. What is the best way to figure out all foods which you are really sensitive to? Are you best off getting some kind of food intolerance blood testing done - ALCAT/Cyrex #10/etc. - or an elimination diet? Also please give some more info about what is included in your elimination diet course as there isn't a very detailed sales page about it.4. I read a lot on your site and love the fact you quote studies... but it is often hard to find details on exactly what quantities of supplements/what exact parameters for treatment were. here are the 2 studies I am particularly interested in: - https://www.ncbi.nlm.nih.gov/pubmed/14643904 (this is the psoriasis study showing 78.8% os psoriasis patients became symptom free after taking bile supplements. But it doesn't give the dose or brand/type of bile used to achieve the results.) - https://www.ncbi.nlm.nih.gov/pubmed/19044219 (this is the study where 25 out of 25 epilepsy patients became seizure free and 75% got off their medications... but I would love to know who did the study/the type of neurofeedback used, etc. so I can get something as near to what worked so well in that study. Is there any way to find out these details?)5. Also, I contacted one neurofeedback place here in the UK and they said because I have psoriasis and reynauds that I should just follow the GAPS diet as my seizures are probably caused by the same mechanism and that neurofeedback would be "fighting my body chemistry" ... this makes no sense to me as my symptoms of skin flare ups and when I feel good/bad in my brain to not tie up... but I just wanted your opinion too.Lastly, if you were to consider creating another course/book/protocol... do oral tolerance step by step. I would buy it.Thanks.
Why does Modafinil give a hangover effect after it wears off? Being a dopamine reuptake inhibitor and not an agonist I'm not expecting for downregulation to happen. Is it tied to its other mechanisms then? Or to nutrient depletion? Also, about dopamine, is it possible for tiny doses of Modafinil (5-10 mg) to give issues such as dopamine hypersensitivity and tardive dyskinesia?
I've been trying out the Ginseng + Ginkgo combo and I like it quite much. Are there any other stacks or single compounds that you would recommend? Possibly with a long half-life, so that they can be used as "core" to which I can optionally add other nootropics.
Hi Joe,Just got back my results from GI map and I have: C. Difficile toxin A and B - elevated Enterotoxigenic E. coli LT/ST - elevated Enterococcus faecalis - elevated Morganella spp. - elevated Pseudomonas spp. - elevated Pseudomonas aeruginosa - elevatedBasically a lot of opportunistic bacteria and pathogens in my gut.Also my SIgA is low at 135 (reference range 510-2010)Is there a regime on your website I should follow. Is this something I should consider using antibiotics for or stick with natural therapies? and do you think this could be related to either psoriasis or epilepsy?Thanks.
What are the best strategies to prevent Modafinil and Nicotine crash?
Sorry Joe, one more question based on my one below about gut infections... what are your thoughts on FMT? (fecal microbial transplant)Thanks.
Hi Joe,Is it safe for people with neurological disorders like epielpsy, depression, MS, etc. where glutamate issues may play a role to take glutamine to help heal the gut lining... or is it best avoided?I'm not sure as they sound very similar! Thanks for any clarification.
Hi Joe, My house has mold and some damp... what is the best test to see if they are causing issues for me body (best tests)?and do you recommend the mercury tri-test for testing if mercury is an issue? (my mother had multiple amalgam fillings and metalwork in her spine)Thanks.
When I tried the Keto diet, my brain felt great and I had great mental clarity ... but I kept on being sick and had really nausea and my psoriasis flared up like crazy, not like the "keto-flu" but this lasted for weeks and got so bad I couldn't carry on with the diet... could this be due to NAFLD or other fat digestion problems?
Hi Joe!I've been battling health issues since three years ago when I got intoxicated by Ciprofloxacin. I've made some health tests recently which has shown: *Low cortisol salivar curve *High DHEA *Low Progesterone *Medium/Low Testosterone *High Estrone/Estradiol I've read that the treatment of choice for low Cortisol is Hydrocortisone, which unfortunately, isn't well tolerated by Fluoroquinolone victims. Is there any reading on SelfHacked or alternative treatment options you know?

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